Amitriptyline 25mg 50 tablets – Free Shipping


Amitriptyline 25mg 50 tablets

Antidepressant (tricyclic antidepressant). Has some analgesic (central genesis), antiserotonin effect.

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Amitriptyline 25mg 50 tablets

Pharmacotherapeutic group:

Antidepressants. Non-selective monoamine reuptake inhibitors. ATX code N06A A09.


Active ingredient: Amitriptyline

1 tablet contains amitriptyline hydrochloride in terms of amitriptyline 25 mg; excipients: lactose monohydrate; microcrystalline cellulose, croscarmellose sodium, hypromellose, magnesium stearate, colloidal anhydrous silicon dioxide, polyethylene glycol 6000, titanium dioxide (E 171), talc, polysorbate 80, carmoisin (E 122).


Severe depression, especially with the characteristic signs of anxiety, agitation and sleep disturbance. Depressive states in schizophrenic patients – in combination with a neuroleptic to prevent exacerbations of hallucinations and paranoid mania. Chronic pain syndrome. Nocturnal enuresis in the absence of organic pathology.


Hypersensitivity to amitriptyline or any of the components of the drug. Recently suffered myocardial infarction. Any kind of blockage or disturbance of the heart rhythm, as well as insufficiency of the coronary arteries. Simultaneous treatment with MAOIs (monoamine oxidase inhibitors) is contraindicated (see section “Interaction with other medicinal products and other types of interactions”). The simultaneous administration of the drug and MAOIs can cause the development of serotonin syndrome (a combination of symptoms that include anxiety, confusion, tremor, myoclonus and hyperthermia). Treatment with amitriptyline can be started 14 days after stopping the use of irreversible nonselective MAOIs and at least 1 day after stopping the use of reversible drugs of moclobemide and selegiline. Treatment with MAOIs can be started 14 days after discontinuation of the drug.

Method of administration and dosage:

Depression. Treatment should be started with low doses and gradually increased with careful monitoring of the clinical effect and signs of drug sensitivity. Doses of more than 150 mg per day (up to 225 mg per day, and sometimes up to 300 mg per day) should be used in a hospital setting.

Adults: first, 25 mg 3 times a day with a gradual increase, if necessary, by 25 mg every second day to 150 mg per day (occasionally up to 225-300 mg per day in a hospital setting). The maintenance dose corresponds to the optimal therapeutic dose.

Patients over 65 years of age: treatment should be started at approximately half the recommended dose, using amitriptyline in the appropriate dosage form, gradually increasing, if necessary, every second day to 100–150 mg per day. An additional dose should usually be taken in the evening. The maintenance dose corresponds to the optimal therapeutic dose.

Duration of therapy. The antidepressant effect usually develops within 2–4 weeks. Antidepressant treatment is symptomatic and should therefore be given for an appropriate period of time, usually up to 6 months after recovery, in order to prevent relapse. Patients with recurrent (unipolar) depression may need supportive therapy for several years to prevent new episodes.

Chronic pain syndrome. Adults. First take 25 mg in the evening. The dose can be gradually increased according to the effect of therapy up to a maximum dose of 100 mg in the evening. For elderly patients, treatment should be started at about half the recommended dose.

Nocturnal enuresis. Children 7-12 years old – 25 mg, over 12 years old – 50 mg 30 minutes – 1 hour before bedtime. The duration of therapy is no more than 3 months.

Decreased renal function: Patients with reduced renal function can be prescribed amitriptyline at normal doses.

Decreased liver function: it is recommended to carefully select the dose and, if possible, determine the content of the drug in the blood serum.

Method of application: increasing the dose is usually carried out by taking the drug in the evening or before bedtime. With maintenance therapy, the total daily dose can be taken once, mainly at bedtime. The tablets should be swallowed whole without chewing and drinking water.

Termination of treatment: in case of termination of treatment, the dose of the drug should be gradually reduced over several weeks.


Shelf life:
3 years.

Storage conditions:
Store in its original packaging at a temperature not exceeding 25 °C.

Produced in Ukraine

Additional information


5mg, 10mg, 20mg