Arrhythmias, tachycardia of excitement, thyrotoxicosis: usually doses are 10-40 mg 3-4 times a day.
Long-term preventive therapy after myocardial infarction: therapy should be started 5-21 days after myocardial infarction. The initial dose is 40 mg 4 times a day for 2-3 days after that the daily dose can be increased to 80 mg 2 times a day.
Pheochromocytoma (only in combination with α-adrenergic receptors): prescribe 60 mg per day for 3 days before surgery; in inoperable cases – 30 mg per day.Elderly patients. The data on the relationship between the level of the drug in the blood and the patient’s age are contradictory. As a result, in elderly patients, the optimal dosage should be determined individually according to the clinical response.
Children: The dosage of Propranolol should be individualized in accordance with the state of the cardiovascular system and the circumstances that led to the need for treatment.
When treating, be guided by the following schemes:Arrhythmia, pheochromocytoma, thyrotoxicosis: the drug should be used in children aged 3 years and older at a dosage of 0.25-0.5 mg / kg body weight 3-4 times a day.Migraine: children aged 3 to 12 years – 20 mg 2-3 times a day, over 12 years old – dosage as for adult patients.
Overdose:Symptoms: dizziness, severe arterial hypotension, bradycardia, arrhythmia, heart failure, collapse, acrocyanosis, convulsions, difficulty breathing, bronchospasm.
Treatment: gastric lavage, the appointment of adsorbing agents. In the absence of signs of pulmonary edema, prescribe infusion of plasma-substituting solutions, if ineffective – epinephrine, dopamine, dobutamine; with heart failure – cardiac glycosides, b-adrenergic agonists, diuretics, glucagon; for convulsions – intravenous diazepam; with bronchospasm – β-adrenostimulants inhaled or parenterally. In the presence of a violation of atrioventricular conduction – 1-2 mg of atropine intravenously (for adults), with low efficiency – the installation of a temporary pacemaker. For ventricular premature beats, use lidocaine (class IA antiarrhythmic drugs are not used). With a decrease in blood pressure, the patient should be in the Trendelenburg position. Hemodialysis is ineffective.
Shelf life: 4 years.
Storage conditions: Store in its original packaging at a temperature not exceeding 25 ° С