active ingredients: captopril, hydrochlorothiazide; 1 tablet contains: captopril 50 mg, hydrochlorothiazide 25 mg;
excipients: potato starch, lactose monohydrate, colloidal anhydrous silicon dioxide, povidone, magnesium stearate.
Combined preparations of ACE inhibitors. Captopril and diuretics. ATX code С09В А01.
Method of administration and dosage:
Captopres-Darnitsa should be taken orally 1 hour before meals, since the absorption of the drug decreases in the presence of food in the stomach.
The dose of the Captopres-Darnitsa is set by the doctor individually, depending on the clinical picture of the disease. The initial dose may be ½ tablet (25 mg captopril and 12.5 mg hydrochlorothiazide) once a day. In the future, if necessary, the maintenance dose can be increased to 1 tablet (50 mg of captopril and 25 mg of hydrochlorothiazide) once a day.
The maximum therapeutic effect occurs 6-8 weeks after the start of treatment. Dose adjustments should be made at 6-week intervals unless clinical manifestations warrant a more rapid dosage change. In case of insufficient decrease in blood pressure, captopril and hydrochlorothiazide can be additionally included in the treatment regimen in the form of monopreparations. In this case, the daily dose of captopril should not exceed 150 mg, hydrochlorothiazide – 50 mg.
Patients with impaired renal function. Since captopril and hydrochlorothiazide are excreted from the body mainly by the kidneys, if their function is impaired, the level of drugs may increase. It is recommended to reduce the dose of the drug: with creatinine clearance from 30 to 80 ml / min, the initial dose is ½ tablet (25 mg of captopril and 12.5 mg of hydrochlorothiazide) once a day in the morning.
Shelf life: 3 years
Produced in Ukraine