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Cardura Doxazosinс Composition:
active ingredient: doxazosin; 2 mg tablets: 1 tablet contains 2.43 mg of doxazosin mesylate, equivalent to 2 mg of doxazosin;
other components: lactose, monohydrate; magnesium stearate; cellulose microcrystalline; sodium lauryl sulfate; sodium starch glycolate (type A).
The drug is indicated for the treatment of hypertension and for most patients it can be used to control blood pressure as monotherapy. If monotherapy for the treatment of arterial hypertension is ineffective, the drug can be used in combination with thiazide diuretics, β-adrenergic receptor blockers, calcium channel blockers and angiotensin-converting enzyme inhibitors.
Benign prostatic hyperplasia.
The drug is indicated for the treatment of urinary tract obstruction, as well as symptoms associated with benign prostatic hyperplasia (BPH). The drug can be prescribed to patients with BPH both in the presence of arterial hypertension and in normal blood pressure.
Dosage & Administration
Cardura medication can be taken with morning and evening.
The drug should be used 1 time per day. The initial dose is 1 mg to minimize the risk of orthostatic hypotension and / or syncope. After 1-2 weeks of initial therapy dose can be increased to 2 mg, and then, if necessary – up to 4 mg. Most of the patients response to treatment is observed when using the drug in a dose ≤4 mg. If necessary, the dose can be increased to 8 mg or up to the maximum recommended dose – 16 mg.
The recommended initial dose of the drug is Cardura 1 mg 1 time a day, in order to minimize the risk of orthostatic hypotension and / or syncope. Depending on the individual characteristics of the patient and urodynamics BPH symptoms, the dose can be increased to 2 mg, 4 mg to then and up to the maximum recommended dose – 8 mg. The recommended dose range selection is 1-2 weeks. The usual recommended dose is 2-4 mg / day.
Elderly patients should use the usual dose for adults.
Patients with impaired renal function should be used the usual dose for adults, since the pharmacokinetic parameters of the drug in kidney function do not change.
Cardura use of the drug is contraindicated in the following categories of patients:
– hypersensitivity quinazoline derivatives (e.g. prazosin, terazosin, doxazosin) or any of the excipients of the formulation;
– cases of orthostatic hypotension in history;
– BPH and concomitant obstruction of the upper urinary tract, chronic urinary tract infections and the presence of stones in the bladder;
– with arterial hypotension (applies only to patients with benign prostatic hyperplasia).