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Pharmacological group: Antihistamines for systemic use. Piperazine derivatives. Code ATH R06A E07.
Active ingredient: Cetirizin Hydrochloride
1 Tablet Zetrin Contains Cetirizin hydrochloride 10 mg Auxiliary substances: lactose monohydrate, starch corn povelon, magnesium giphromellose stearate; polyethylene glycols; titanium dioxide (E 171) Talc sorbic acid; Polysisses; Dimethicone.
Film-coated tablets. Basic physical and chemical properties: round biconvex film-coated tablets, white, with a notch on one side and smooth on the other side.
Nasal symptoms of seasonal and chronic allergic rhinitis (Rinorea, itching in the nose, sneezing), non-nasal symptoms associated with conjunctivitis. Itching, urticaria of various types, including chronic idiopathic urticaria.
Method of administration and dosage:
Patients suffering from impaired kidney function, the dose should be adjusted with an individual basis, taking into account the clearance of kidneys, age and body weight.
Patients with moderate or severe renal impairment There are no data on the benefit / risk ratio for patients with impaired renal function. Since cetirizine is excreted by the kidneys, if alternative treatment is not possible, the intervals between doses of the drug should be determined individually, depending on the renal function.
Patients with impaired liver function (subject to normal renal function) dose adjustment is not required.
The duration of treatment is determined by the doctor depending on the course of the disease.
Cetrin is excreted by the kidneys, therefore, in case of renal failure, the dose should be reduced to 5 mg per day. Elderly patients with normal renal function do not require dose adjustment. When taken in therapeutic doses, no clinically significant interactions with alcohol were observed (at blood alcohol levels of 0.5 g / l). However, it is recommended to avoid concomitant use with alcohol. It is recommended to prescribe with caution to patients with epilepsy and patients at risk of seizures, not to use in patients with hereditary galactose intolerance, with
Lapp lactase deficiency or impaired glucose-galactose malabsorption. The drug contains lactose monohydrate. If you have a history of intolerance to some sugars, consult your doctor before taking this medication. Use with caution in patients prone to urinary retention (spinal injury, prostatic hyperplasia), since cetirizine may increase the risk of urinary retention. Antihistamines suppress allergic skin test, therefore, before taking it, the drug should be discontinued 3 days before the study (withdrawal period).
Interaction with other medicinal products and other types of interactions:
A study of the interaction of cetirizine with pseudoephedrine, cimetidine, antipyrine, ketoconazole, erythromycin, azithromycin was carried out. The study did not confirm the pharmacokinetic interaction of these agents with cetirizine. When taken together with theophylline, the clearance of cetirizine decreases, which can lead to the accumulation and overdose of cetirizine. There is no evidence of an increase in the effect of sedatives when using cetirizine in therapeutic doses. But you should avoid the use of sedatives while taking cetirizine.
The absorption of cetirizine does not decrease with food intake, although the absorption rate decreases by 1 hour. Alcohol and / or central nervous system (CNS) depressants, when used together with cetirizine, can cause additional impairment of attention and impairment of performance, although cetirizine does not potentiate the effect of alcohol (at blood alcohol levels of 0.5 g / l).
Store in its original packaging at a temperature not exceeding 25 ° C.
Produced in India