Hypertension. The drug is indicated for the treatment of hypertension and for most patients it can be used to control blood pressure as monotherapy. In the case of the ineffectiveness of monotherapy for the treatment of hypertension drug can be used in combination with thiazide diuretics, β-adrenergic blockers, calcium channel blockers and angiotensin-converting enzyme inhibitors.
Benign prostatic hyperplasia. The drug is indicated for the treatment of urinary tract obstruction and symptoms associated with benign prostatic hyperplasia (BPH). The drug can be administered to patients with BPH as the presence of hypertension and with normal blood pressure.
– Hypersensitivity to quinazoline derivatives (eg prazosin, terazosin, doxazosin) or to any of the excipients of the drug;
– Cases of orthostatic hypotension in history;
– BPH and concomitant obstruction of the upper urinary tract, chronic urinary tract infection and the presence of stones in the bladder;
– Hypotension (applies only to patients with BPH).
Doxazosin as monotherapy is contraindicated in patients with overflow bladder or anuria with advanced renal failure or not.
Dosage & Administration
Doxazosin can be taken in the morning and evening.
Hypertension. The drug should be used 1 time per day. The initial dose is 1 mg to minimize the risk of orthostatic hypotension and / or syncope. After 1-2 weeks of initial therapy dose can be increased to 2 mg, and then, if necessary, and 4 mg. Most patients respond to therapy observed when using the drug at a dose of 4 mg or lower. If necessary, the dose can be increased to 8 mg or to a maximum recommended dose – 16 mg.
Benign prostatic hyperplasia. The recommended starting dose is 1 mg doxazosin 1 per day to minimize the risk of orthostatic hypotension and / or syncope. Depending on the individual patient’s urodynamics and BPH symptoms, the dose can be increased to 2 mg, then to 4 mg and the maximum recommended dose – 8 mg. The recommended dose range selection is 1-2 weeks. The usual recommended dose is 2-4 mg per day.
Elderly patients should use the usual dose for adults.
Patients with impaired renal function should use the usual dose for adults as pharmacokinetics of the drug in impaired renal function do not change.
Doxazosin is not eliminated from the body by hemodialysis.