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active ingredients: enalapril maleate, hydrochlorothiazide; 1 tablet contains in terms of 100% substance: enalapril maleate 10 mg, hydrochlorothiazide 25 mg;
excipients: lactose monohydrate, potato starch, povidone, calcium stearate.
Dosage & Administration
The initial dose is 1 tablet (12.5 Enalozid; Enalozid 25; Enalozid Forte) 1 time per day. If the desired effect is absent, the daily dose was increased to two tablets one time per day. The maximum dose – 2 tablets per day.
Prior diuretic therapy. If a patient is already taking diuretics, it is recommended to cancel or reduce the dose of the diuretic 2-3 days before starting therapy Enalozid in order to avoid a sharp decline in blood pressure. Symptomatic hypotension may occur at the beginning of therapy and more common in patients whose previous therapy with diuretics has caused disruption of water and electrolyte balance.
Impaired renal function. For patients with impaired moderate and severe renal impairment (creatinine clearance ≤30 mL / min) thiazides may not be sufficiently effective. Patients with creatinine clearance 30-80 ml / min can be used only after a preliminary selection of the dose of each component of the drug. In light violations recommended dose of enalapril maleate in renal function, which is taken separately, is 5-10 mg.
Hypersensitivity to any component of the drug and other sulfonamide derivatives. Angioedema in history associated with ACE inhibitors, as well as hereditary or idiopathic angioedema. Severe renal (creatinine clearance <30 mL / min) or hepatic impairment. Anuria. Renal artery stenosis. During hemodialysis. Condition after kidney transplantation. Severe electrolyte imbalance. Hemodynamically significant aortic stenosis. During pregnancy and breastfeeding. Childhood.
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