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active ingredients: amlodipine besilate and valsartan; 1 tablet contains amlodipine besylate 13.87 mg in terms of amlodipine base 10 mg and valsartan 160 mg;
excipients: microcrystalline cellulose, crospovidone, magnesium stearate, colloidal silicon dioxide, polyethylene glycol (macrogol) 4000, talc, hypromellose, titanium dioxide (E 171), iron oxide yellow (E172), iron oxide red (E 172).
Essential hypertension in patients whose blood pressure is not regulated by monotherapy with amlodipine or valsartan.
Dosage & Administration
Patients whose blood pressure adequately controlled by one of the monotherapies (amlodipine or valsartan) may be converted to combination therapy with Exforge. The recommended dose – one tablet per day. Exforge tablets can be taken with or without food. It is recommended to take the drug, washing it down with water.
Patients taking valsartan and amlodipine separately, can be transferred to Exforge which contains the same component doses.
individual titration with the components (amplodipina and valsartan) is recommended before switching to the fixed dose combination. In the case of clinical need, you can consider the possibility of immediate replacement monotherapy to a combination of fixed doses.
The maximum daily dose – 1 tablet of the drug Exforge 5/80 mg or 1 tablet of the drug Exforge 5/160 mg, or 1 drug Exforge 10/160 mg tablet (the maximum allowable dose of the components of the drug – 10 mg on the content of amlodipine, 320 mg – in content valsartan).
Hypersensitivity to the active substance, dihydropyridine derivatives or any of the excipients of the drug.
Severe hepatic impairment, biliary cirrhosis or cholestasis.
Severe renal impairment (glomerular filtration rate <30 mg / min / 1.73 m2); as the drug is contraindicated in patients who are on dialysis.
According to the information on the safety of amlodipine:
– Obstruction of the left ventricular outflow tract (eg aortic stenosis, severe);
– Haemodynamically unstable heart failure after acute myocardial infarction.