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Hartil H Composition:
active ingredients: ramipril, hydrochlorothiazide;
1 tablet contains 5 mg of ramipril and 25 mg of hydrochlorothiazide;
excipients: lactose, hypromellose, crospovidone, microcrystalline cellulose, sodium stearyl fumarate.
Essential hypertension in patients in whom combination therapy is recommended (ramipril and hydrochlorothiazide).
Doage & Administration
Hartil H is administered orally. Take 1 time per day, in the morning. The drug can be applied regardless of the meal. The tablets are swallowed whole, drinking plenty of fluids. The drug should not chew or crush.
Appoint a combined preparation Hart-H is recommended only after individual selection of doses of each component. The usual starting dose is 2.5 mg of ramipril and 12.5 mg of hydrochlorothiazide. If necessary, the dose can be gradually increased to achieve optimal blood pressure, the maximum permissible dose – 10 mg of ramipril and 25 mg of hydrochlorothiazide daily.
Patients who take diuretics
Be wary appoint patients who received diuretics, as hypotension may occur at the beginning of treatment. It is necessary to reduce the dose of diuretic or discontinue diuretic before starting treatment with Hart-H.
Elderly patients and patients with impaired renal function
For elderly patients, and patients with creatinine clearance 30 to 60 mL / min the dose of each of the individual components (ramipril and hydrochlorothiazide) should be carefully selected to go to Hart-H.
Dose Hart-H product should be as low as possible. The maximum recommended daily dose is 5 mg of ramipril and 25 mg of hydrochlorothiazide.
The initial dose should be lower and subsequent dose titration should be more gradual because of greater possibility of side effects, especially in elderly patients (over 65 years).
Abnormal liver function
Treatment Hartilom-H patients with mild or moderate hepatic impairment should be started under medical supervision and the maximum daily dose of 2.5 mg of ramipril and 12.5 mg of hydrochlorothiazide.
Do not use the Hartil H, if you have severe hepatic impairment and / or cholestasis.
– hypersensitivity to ramipril or other ACE inhibitors, hydrochlorothiazide and other thiazide diuretics or other derivatives of sulfonamides, as well as any auxiliary substance;
– angioedema due to the introduction of ACE inhibitors in history;
– hereditary / idiopathic angioedema;
– renal artery stenosis (bilateral or unilateral in patients with one kidney);
– severe renal dysfunction (creatinine clearance <30 mL / min) or anuria;
– severe liver and / or cholestasis; hepatic encephalopathy.
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