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active substance: hydroxychloroquine; 1 tablet contains hydroxychloroquine sulfate 200 mg
excipients: lactose, povidone, corn starch, magnesium stearate shell: Opadry OY-L-28900 (hypromellose, titanium dioxide (E 171), polyethylene glycol, lactose).
Malaria – for the relief of acute attacks and the suppression of malaria caused by plasmodium vivax, p. ovale and p. malariae, as well as sensitive p. falciparum; for the radical treatment of malaria caused by susceptible strains of p. falciparum.
Rheumatic and dermatological diseases – systemic lupus erythematosus, discoid lupus erythematosus, rheumatoid arthritis, chronic juvenile arthritis, dermatological diseases caused by sunlight.
Method of administration and dosage:
Hydroxychloroquine is used only orally. tablets are taken with meals or washed down with a glass of milk. all doses are given for hydroxychloroquine sulfate and are not equivalent to hydroxychloroquine base.
Rheumatic diseases. Plaquenil has a cumulative effect, and it takes several weeks to achieve its therapeutic effect, while minor side effects can appear relatively early. If within 6 months the patient’s condition does not improve, the drug is canceled.
Rheumatoid arthritis. The initial dose for adults is 400–600, the maintenance dose is 200–400 mg / day.
Chronic juvenile arthritis. The dose should not exceed 6.5 mg / kg of body weight or 400 mg / day, the minimum effective dose should be prescribed.
Systemic and discoid lupus erythematosus. The initial dose for adults is 400-800, the maintenance dose is 200-400 mg / day.
Increased light sensitivity. Treatment should be limited to periods of maximum light exposure. For adults, a dose of 400 mg / day may be sufficient.
Suppression of malaria. For adults – 400 mg on the same day of the week. For children over 6 years of age, the weekly suppressive dose is 6.5 mg / kg, but regardless of body weight, it should not exceed the adult dose.
If conditions permit, suppressive therapy should be started 2 weeks before travel to the endemic area. If this is not possible, adults can be given an initial double dose of 800 mg, children – 12.9 mg / kg of body weight (but not more than 800 mg), divided into 2 doses with an interval of 6 hours. Suppressive therapy should be continued for 8 weeks after departure from an endemic zone.
Treatment for acute attacks of malaria. The initial dose in adults is 800 mg, then 400 mg after 6 or 8 hours and 400 mg for the next two days (only 2 g of hydroxychloroquine sulfate). As an alternative method, a single dose of 800 mg is possible. The dose for adults, as well as for children, can be calculated based on body weight (see below).
For children over the age of 6 years, a total dose of 32 mg / kg body weight (but not exceeding 2 g) is applied for more than 3 days as follows:
– 1st dose – 12.9 mg / kg (but not more than 800 mg per dose);
– 2nd dose – 6.5 mg / kg (but not more than 400 mg) 6 hours after the 1st dose;
– 3rd dose – 6.5 mg / kg (but not more than 400 mg) 18 hours after the 2nd dose;
– 4th dose – 6.5 mg / kg (but not more than 400 mg) 24 hours after the 3rd dose.
5 ° C to 25 ° C
Produced in Spain