Isoket injection 0.1% 10ml/10 ampoules

Isoket Indications

Unstable angina, acute myocardial infarction, acute left ventricular failure, to facilitate revascularization, as well as to prevent or increase the length of neovascularization, as well as to prevent or reduce the severity of coronary spasm.

Dosage & Administration

The drug is used in / or intracoronary for intensive therapy in adults only in the hospital! The dose is determined individually taking into account the clinical condition of the patient and, with constant monitoring of the clinical and hemodynamic parameters.

Therapy is started with a dose of 2 mg / hr, gradually increasing it until required for optimal therapeutic effect. The average dose of 7.5 mg / hr. The maximum dosage normally does not exceed 10 mg / hr, but in patients with heart failure, the dose can be increased to 10-50 mg / h. To dilute the drug is used only in / in the introduction!
Intracoronary administration. Apply during percutaneous transluminal koronaroangioplastiki. Usually the drug is administered as a bolus injection prior to inflating the balloon at a dose of 1 mg. Next, the drug can be administered over 30 minutes in doses not to exceed 5 mg.

Mode of application
0.1% solution of the drug administered:
pre-diluted in the form of a continuous / infusion with automatic infusion systems;
undiluted using a syringe-pump in a hospital under constant monitoring of the performance of the cardiovascular system. Depending on the disease and its severity, in addition to the normal inspection (symptoms, blood pressure, heart rate, urine output) used invasive methods for determining the hemodynamic parameters. The ampules should be opened under aseptic conditions immediately prior to use. Divorced rr should be used immediately.

Contradictions

– hypersensitivity to isosorbide dinitrate, other nitrate compounds or other ingredients;
– acute circulatory failure (shock, circulatory collapse);
– in case of cardiogenic shock in case of impossibility of correction of left ventricular end-diastolic pressure by suitable measures;
– severe hypotension (systolic blood pressure <90 mm Hg, diastolic blood pressure <60 mm Hg….);
– hypertrophic obstructive cardiomyopathy;
– constrictive pericarditis;
– cardiac tamponade;
– primary pulmonary disease (because of the risk of hypoxia, which can be caused by the redistribution of blood flow in areas of hyperventilation);
– toxic pulmonary edema;
– state, accompanied by increased intracranial pressure (hemorrhagic stroke, traumatic brain injury);
– children up to age 18;
– lactation.