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active ingredient: lisinopril; 1 tablet contains lisinopril (in the form of dihydrate) 10 mg; excipients: calcium hydrogen phosphate dihydrate, mannitol (E 421), corn starch, corn starch, magnesium stearate, talc, colloidal silicon dioxide, yellow iron oxide E 172 (in tablets Lopril Bosnalek 10 mg and 20 mg), red iron oxide E 172 (in tablets Lopril Bosnalek 20 mg).
Hypertension, heart failure (symptomatic treatment), acute myocardial infarction (short-term treatment (6 weeks) in patients with stable hemodynamics within 24 hours after acute myocardial infarction), initial diabetic nephropathy in patients with type II diabetes mellitus with arterial hypertension.
Dosage & Administration
Doses are assigned individually for each patient, depending on its state.
Essential and renovascular hypertension: The recommended initial dose – 2.5 mg / day; maintenance dose – 10-20 mg / day. The maximum dose – 40 mg / day. Dose does not increase by more than 10 mg to 2 week intervals.
Heart failure: the recommended initial dose – 2.5 mg / day maintenance dose – 5-10 mg / day. The maximum daily dose – 20 mg / day.
Acute myocardial infarction: patients with stable hemodynamic parameters within 24 hours after the onset of symptoms of acute myocardial infarction initial dose of 5 mg / day at 24 hours – 5 mg / day, after 48 hours – 10 mg / day. The maintenance dose for 6 weeks or more – 10 mg / day.
Patients with systolic blood pressure <120 mm Hg. Art. in the first 3 days after infarction administered 2.5 mg / day, followed by a maintenance dose of 5 mg / day. If the systolic blood pressure in the treatment decreased to 100 mm Hg. Art., the maintenance dose should be temporarily reduced from 5 to 2.5 mg / day. If hypotension is held after reducing the dosage, the drug should be discontinued. Lopril Bosnalek should not be administered to patients who have a systolic blood pressure <90 mm Hg. Art.
The dosage scheme in renal disease: Patients with creatinine clearance above 30 mL / min the usual starting dose is prescribed according to the statement. When creatinine clearance 30 to 10 mL / min, the initial dose – 2.5-5 mg / day (depending on indication). When creatinine clearance <10 ml / min and in patients on hemodialysis, the initial dose is 2.5 mg / day.
Hypersensitivity to the drug, angioneurotic edema (associated with the intake of ACE inhibitors in history), hereditary and idiopathic angioedema, aortic stenosis, renal artery stenosis, acute renal failure with a constantly high blood pressure during pregnancy and lactation, child age.
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