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Pharmacological group: Antihistamines for systemic use. Code ATX R06A X15.
Dosage form: Pills. Basic physical and chemical properties: tablets of a flat-cylindrical shape with a chamfer and a line, white or white with a yellowish tinge.
Active ingredient: mebhydrolin;
1 Tablet contains mebhydrolin 100 mg. Auxiliary substances: lactose, potato starch, microcrystalline cellulose, povidone, silicon colloidal dioxide, magnesium stearate.
Prevention and treatment of seasonal allergic rhinitis, pollinosis, urticaria, food and drug allergies, dermatoses, accompanied by itching (eczema, neurodermatitis).
Increased sensitivity to the active substance or other components of the drug, ulcerative ulcer of the stomach and duodenum during the period of exacerbation, inflammatory diseases of the digestive tract, pylorostenosis, prostate gland hyperplasia, glaucoma, epilepsy, heart rate disorders.
Method of administration and dosage:
The drug is taken inside after meals.
The active substance of the drug – mebhydrolin – refers to antihistamine drugs, is a blocker of Hl-histamine receptors. Weakens the spasmogenic effect of histamine on the smooth muscles of the bronchi, intestines, and also affects the permeability of blood vessels.
Mebhydrolin is rapidly absorbed from the digestive tract. Bioavailability is 40-60%. The therapeutic effect is achieved in 15-30 minutes, the maximum effect is observed in 1-2 hours. The drug practically does not penetrate the blood-brain barrier. Metabolized in the liver by methylation. It is excreted from the body by the kidneys.
Interaction with other medicinal products and other types of interactions:
The drug potentiates the effect of hypnotics, sedatives and other drugs that depress the central nervous system, as well as alcohol.
During the use of the medicinal product, it is not recommended to consume alcoholic beverages and medications that contain ethanol. The drug should be used with caution in patients with severe hepatic and / or renal impairment (dose adjustment and an increase in the intervals between doses may be required). The drug contains lactose, therefore, patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.
The ability to influence the reaction rate when driving or operating machinery: During the use of the drug, it is not recommended to drive vehicles or work with other mechanisms that require concentration of attention and speed of psychomotor reactions.
Application during pregnancy or lactation: The drug is contraindicated during pregnancy or lactation.
Symptoms: confusion, drowsiness, lack of coordination of movements, dry mouth. Treatment: gastric lavage to clean lavage water, intake of activated charcoal inside, forced diuresis. Further treatment is symptomatic.
From the side of the organs of vision: blurred vision. From the gastrointestinal tract: dyspeptic symptoms (heartburn, nausea, pain in the epigastric region), irritation of the mucous membrane of the digestive tract. On the part of the kidneys and urinary system: urinary disorders. On the part of the nervous system: headache, dizziness, paresthesia, fatigue, drowsiness, slowing down of the reaction rate, tremor, irritability, anxiety (at night). On the part of the blood and lymphatic system: granulocytopenia, agranulocytosis. From the immune system, skin and subcutaneous tissue: hypersensitivity reactions, including itching, rashes, urticaria, Quincke’s edema. Children sometimes have paradoxical reactions: increased agitation, tremors, sleep disturbances.
Store in its original packaging at a temperature not exceeding 25 °C.
Produced in Ukraine
Manufacturer PJSC “Pharmaceutical Firm” Darnitsa “.
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