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The drug should not be used to treat chronic conditions such as gastroparesis, dyspepsia and gastroesophageal reflux disease, or as an adjunct to surgical or radiological procedures.
Neurological disorders. Extrapyramidal disturbances may occur, especially in children and / or with high doses. These reactions are usually observed at the beginning of treatment and may occur after a single use. If extrapyramidal symptoms develop, metoclopramide should be discontinued immediately. In general, these effects completely disappear after discontinuation of treatment, but may require symptomatic treatment (benzodiazepines for children and / or anticholinergic antiparkinsonian drugs for adults).
Between each administration of the drug, even in the case of vomiting with the elimination of the dose of the drug along with the vomit, in order to avoid overdose, an interval of at least 6 hours must be observed. Long-term treatment with drug can lead to tardive dyskinesia, which is potentially irreversible, especially in the elderly. Treatment should not be continued for more than 3 months due to the risk of tardive dyskinesia.
Treatment should be discontinued if clinical signs of tardive dyskinesia appear. With the use of the drug in combination with antipsychotics, as well as with drug alone, the development of neuroleptic malignant syndrome has been reported. In the event of symptoms of neuroleptic malignant syndrome, the use of the drug should be stopped immediately and appropriate treatment initiated.
With regard to patients with concomitant neurological diseases and patients receiving treatment with other drugs acting on the central nervous system, you need to be especially careful. The use of the drug may also increase the symptoms of Parkinson’s disease.
Keep out of the reach of children in its original packaging at a temperature not exceeding 25 ° C.
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