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active ingredient: metoprolol; 1 tablet contains metoprolol tartrate, in terms of 100% substance – 50 mg; excipients: lactose monohydrate, microcrystalline cellulose crospovidone; povidone, calcium talc stearate.
arterial hypertension; angina pectoris (including postinfarction); arrhythmia (including supraventricular tachycardia); prevention of cardiac death and re-infarction after the acute phase of myocardial infarction; as part of complex therapy for thyrotoxicosis; prevention of migraine attacks.
Dosage and administration
Metoprolol is designed for daily use, preferably in the morning. The tablet should be taken without chewing, drink sufficient amount of drinking water. During the selection of doses should monitor your heart rate to prevent bradycardia. The maximum daily dose – 400 mg.
Hypertension. The recommended dose is 100 mg (once in the morning or distributing in two stages – morning and evening).
Angina. The recommended dose is 50-100 mg 2-3 times a day.
Arrhythmia. The recommended dose is 50 mg 2-3 times a day.
Myocardial infarction (preferably start the treatment within the first 12 hours after the onset of chest pain). The recommended dose is 50 mg every 6 hours for 48 hours, supporting the recommended daily dose – 200 mg in two divided doses. The course of treatment – at least 3 months.
Hyperthyroidism (thyrotoxicosis). The recommended dose is 50 mg 4 times daily. When the therapeutic effect of the dose should be gradually reduced.
Prophylaxis of migraine attacks. The recommended daily dose is 100-200 mg a day divided into 2 doses.
– Hypersensitivity to any component of the drug or other β-blockers;
– Atrioventricular block (II and III degree), sinoatrial block;
– Sick sinus syndrome;
– Decompensated heart failure (pulmonary edema, hypoperfusion syndrome or hypotension);
– Severe bradycardia (heart rate ≤ 50 for 1 min);
– Cardiogenic shock;
– Severe disorders of peripheral blood circulation pain or trophic changes;
– Hypotension (systolic blood pressure <100 mmHg);
– Asthma, severe chronic obstructive bronchopulmonary diseases;
– Metabolic acidosis;
– Untreated pheochromocytoma.
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