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active substance: moxonidine; 1 tablet contains moxonidine 0.2 mg or 0.4 mg; Excipients: lactose monohydrate, povidone, lactose anhydrous, crospovidone, magnesium stearate; tablet shell: hypromellose, titanium dioxide (E 171), macrogol, iron oxide red (E 172), iron oxide yellow (E 172).
Hypersensitivity to the active substance or to any component of the drug.
Syndrome of weakness of the sinus node.
Bradycardia (at rest – below 50 beats / min).
AV-blockade of the II and III degree.
Dosage & Administration
The standard starting dose of moxonidine is 0.2 mg per day (1 tablet of Moxonidine Xanthis at a dosage of 0.2 mg in the morning). The maximum single dose is 0.4 mg. The maximum daily dose – 0.6 mg – is used in 2 doses. The dose should be selected individually, depending on the patient’s response.
Moxonidine Xanthis can be taken with or without food, with a small amount of fluid.
For patients with moderate or severe renal insufficiency, the initial dose of moxonidine is 0.2 mg per day. If necessary and in case of good tolerability, the dose can be increased to 0.4 mg per day for patients with moderate renal insufficiency and up to 0.3 mg per day for patients with severe renal insufficiency (see section “Special warnings and precautions for use”).
For patients on hemodialysis, the initial dose of Moxonidine Xanthis is 0.2 mg per day. If necessary and in case of good tolerability of the drug, the dose can be increased to 0.4 mg per day.
Moxonidine Xanthis is not recommended for use in children due to a lack of data on safety and efficacy in this group.