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Pharmacological group: Non-selective non-steroidal anti-inflammatory drugs (NSAIDs). ATX code M01A X17.
Active ingredient: Nimesulide
1 single packet of 2 g of granules contains 100 mg of nimesulide. Excipients: macrogol cetostearyl ether, sucrose, maltodextrin, citric acid, orange flavor
Treatment of acute pain, primary dysmenorrhea. Nimesil should only be used as a second-line drug. The decision to prescribe nimesulide should be made on the basis of an assessment of all risks for a particular patient.
Nimesulide can be taken through various forms, and oral form may work the best when taken for short durations. It is best to avoid it if you have any serious illnesses that are mentioned above.
Method of administration and dosage:
In order to reduce the incidence of adverse reactions, it is necessary to use the minimum effective dose for a short time (see Section “Peculiarities of use”). The maximum duration of the course of treatment with Nimesil is 15 days.
Adults. 1 packet (100 mg of Nimesil) 2 times a day after meals.
Elderly patients. Elderly patients do not need to reduce the daily dose (see section “Pharmacokinetics”).
Children. Medicines containing Nimesil are contraindicated in children under 12 years of age (see also the section “Contraindications”). Given the pharmacokinetic profile in adults and the pharmacodynamic characteristics of nimesulide, dose adjustment for children aged 12 to 18 years is not needed.
Impaired renal function. Given the pharmacokinetics, dose adjustment is not required in patients with mild or moderate renal impairment (creatinine clearance 30-80 ml / min), while in severe renal impairment (creatinine clearance <30 ml / min), Nimesil is contraindicated (see . section “Contraindications” and “Pharmacokinetics”).
Liver dysfunction. The use of the drug Nimesil is contraindicated in patients with impaired liver function (see section “Pharmacokinetics”). Adverse reactions can be minimized by using the drug for a short period of time necessary to control symptoms (see section “Peculiarities of use”).
Mode of application. Pour the contents of the package into a glass with still water. Stir with a spoon until an orange-scented suspension is obtained. Drink the suspension immediately after stirring.
The ability to influence the reaction rate when driving or operating machinery:
The study of the effect of drugs containing nimesulide on the ability to drive vehicles or other mechanisms has not been carried out, however, patients who experience dizziness, vertigo or drowsiness after taking nimesulide should refrain from driving vehicles or other mechanisms.
Symptoms of acute NSAID overdose are usually limited to the following: apathy, drowsiness, nausea, vomiting and epigastric pain, which are usually reversible with maintenance therapy. Gastrointestinal bleeding is possible. Rarely possible arterial hypertension, acute renal failure, respiratory depression and coma. There have been reports of anaphylactoid reactions when using therapeutic doses of NSAIDs, which can occur in case of overdose. In case of overdose of NSAIDs, patients should be provided with symptomatic and supportive treatment. There are no specific antidotes. There is no information on the withdrawal of nimesulide by hemodialysis, but if we take into account its high degree of binding to plasma proteins (up to 97.5%), it is unlikely that dialysis will be effective in overdose. In the presence of symptoms or after a severe overdose within 4 hours after taking the drug, patients can be prescribed vomiting and / or activated charcoal (60-100 g for adults), and / or an osmotic laxative. Forced diuresis, urinary obstruction, hemodialysis, or hemoperfusion may be ineffective due to the high degree of protein binding. Kidney and liver function should be monitored.
Shelf life: 3 years.
Store in its original packaging at a temperature not exceeding 25 °C.
Nimesulide is a non-steroidal anti-inflammatory drug that inhibits the Cox-II enzyme that causes pain and inflammation. It reduces the production of free radicals that are produced by neutrophils during inflammation. It also inhibits the synthesis of platelet inhibiting factors, thereby blocking the release of messengers that causes pain and inflammation.
The maximum length of a course of nimesulide therapy is 15 days
Nimesulide and Paracetamol belong to the same class of medicines, and both are equally effective in reducing pain, inflammation, and fever. However, Nimesulide is not advised in children, and it is less effective if the child has inflammation in the upper respiratory tract. Nimesulide and paracetamol should not be taken together, and either medicine should be taken under expert medical advice to avoid side effects or overdose.
Ibuprofen has been used as a painkiller and as an anti-inflammatory for decades. Nimesulide is also an anti-inflammatory and analgesic drug used to treat similar conditions. However, Nimesulide overpowers Ibuprofen and has been proven to have stronger effects and provide faster results in terms of pain, fever, and inflammation. These should not be taken together as it may lead to severe complications and gastric ulcers.
As it has a proven history of treating mild migraines, Nimesulide works best and is effective when taken for headaches as prescribed. If you have recurring headaches, this drug is not advised for long-term use, and you should consult your doctor.
Nimesulide works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15 minutes of taking the medicine. For best results, it should be taken with food or milk to reduce the chances of a stomach upset.
Nimesulide is an NSAID drug and is safe to use short term(no more than 15 days). When consumed long-term or in excess, Nimesulide can cause acute renal failure in individuals.
Yes, Nimesulide is a non-steroidal anti-inflammatory drug (NSAID). It is best known for the treatment of acute inflammation, pain, and fever. It also reduces pain and inflammation associated with certain diseases or conditions.
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