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Pharmacological group: Drugs used in the case of amoebiasis and other protozoal infections. Nitroimidazole derivatives. Ornidazole. ATC code P01A B03.
Active ingredient: Ornidazole
1 tablet contains ornidazole 500 mg; auxiliary substances: corn starch, microcrystalline cellulose, hypromellose, magnesium stearate, dry mixture “Opadry II white”, which contains: titanium dioxide (E 171), talc, polyethylene glycol, polyvinyl alcohol.
Ornidazole is an antiprotozoal and antibacterial agent, a derivative of 5-nitroimidazole. Active against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamlia (Gardia intestinalis), as well as some anaerobic bacteria such as Bacteroides, Clostridium spp., Fusobacterium spp. and anaerobic cocci.
According to the mechanism of action, ornidazole is a DNA-tropic drug with selective activity against microorganisms that have enzyme systems capable of reducing the nitro group and catalyzing the interaction of proteins of the feridoxin group with nitro compounds.
After the penetration of the drug into the microbial cell, the mechanism of its action is due to the restoration of the nitro group under the influence of nitroreductases of the microorganism and the activity of the already reduced nitroimidazole.
Recovery products form complexes with DNA, causing its degradation, disrupt the processes of DNA replication and transcription. In addition, the metabolic products of the drug have cytotoxic properties and disrupt the processes of cellular respiration.
Trichomoniasis (genitourinary infections in women and men caused by Trichomonas vaginalis). Amebiasis (all intestinal infections caused by Entamoeba histolytica, including amoebic dysentery, all extraintestinal forms of amoebiasis, especially amoebic liver abscess) Giardiasis. Prevention of infections caused by anaerobic bacteria during surgery, especially in the colon and gynecological operations.
Hypersensitivity to the drug or to other nitroimidazole derivatives. Lesions of the central nervous system (epilepsy, brain damage, multiple sclerosis). Pathological blood lesions or other hematological abnormalities.
Method of administration and dosage:
Ornidazole is taken orally after a meal with a small amount of water.
Recommended dosage regimen of the drug: a) the course of treatment is 1 day: – adults and children weighing more than 35 kg – 3 tablets to take in the evening; – The daily dose for children weighing from 20 kg to 35 kg is 25 mg of ornidazole per 1 kg of body weight and is applied in 1 dose. b) the course of treatment is 5 days: – adults and children weighing more than 35 kg – 2 tablets (1 tablet in the morning and in the evening). Children weighing less than 35 kg are not recommended. To eliminate the possibility of re-infection, the sexual partner must undergo the same course of treatment.
Giardiasis. Adults and children weighing more than 35 kg are prescribed 3 tablets once in the evening, children weighing less than 35 kg – a single dose at the rate of 40 mg / kg of body weight per day. The duration of treatment is 1-2 days.
Prevention of infections caused by anaerobic bacteria. The duration of postoperative therapy, as a rule, is 5-10 days, but it should be determined based on the clinical data of the operated patient.
Ornidazole-Zdorov’e tablets should be prescribed after the state of the operated patient has stabilized, and when it is possible to take the tablets alone. Assign 1 tablet every 12 hours. For children, the daily dose is 20 mg per 1 kg of body weight in 2 doses for 5-10 days. For the prevention of mixed infections, Ornidazole-Health should be used in combination with aminoglycosides, antibiotics of the penicillin and cephalosporin series. Medicines should be used separately.
Application during pregnancy or lactation:
During the experiment, the drug has no teratogenic or toxic effect on the fetus. Since there have not been any controlled studies involving pregnant women, it is possible to prescribe the drug in early pregnancy or during lactation only when the expected benefit to the mother outweighs the potential risk to the fetus / child.
Store in its original packaging at a temperature not exceeding 25 °C.
Produced in Ukraine
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