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treating the of idiopathic Parkinson’s disease symptoms of adults as monotherapy (without levodopa) or in combination with levodopa during the late stages of the disease before when the effect of levodopa is reduced or becomes unstable and oscillation occurs therapeutic effect (phenomenon of “on-off”).
Symptomatic treatment of idiopathic restless legs syndrome of moderate to severe in adults in doses no higher than 0.75 mg.
Hypersensitivity to pramipexole or any other component of the drug.
Dosage & Administration
Tablet is taken orally, regardless of the meal, with water.
Parkinson’s disease. The daily dose is divided into three equal parts in the reception.
Initial treatment. As shown below, the dose should be increased gradually, starting with 0.375 mg / day every 5-7 days. In cases where patients do not arise intolerable side effects, the dose should be titrated to achieve a maximal therapeutic effect.
Dose escalation scheme of Pramipex
Week Dose, mg Total daily dose, mg
1st 3 x 0,125 0,375
2nd 3 x 0,25 0,75
If further increasing the dose daily dosage should be increased by 0.75 mg per week to a maximum, which is 4.5 mg / day.