· Painful muscle spasm.
· Spasticity due to multiple sclerosis.
· Spasticity due to spinal cord injury.
· Spasticity due to brain damage.
Hypersensitivity to tizanidine or to any of the excipients of the drug.
Severe hepatic impairment.
Concomitant use of tizanidine with strong inhibitors of CYP1A2, such as fluvoxamine or ciprofloxacin.
Dosage & Administration
Sylarud has a narrow therapeutic range and high variabylnist tytsanidyn concentration in plasma in different patients. Therefore, it is important to use optimal doses according to patient need.
Treatment should start with a low dose of 2 mg, which makes the risk of adverse effects of the drug minimal. When needed the dose gradually increase with all the necessary precautions.