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Composition active ingredient: sotalol; 1 tablet contains sotalol hydrochloride 80 mg or 160 mg; excipients: corn starch, lactose, sodium starch (type A), hydroxypropyl cellulose, colloidal silicon dioxide, magnesium stearate.
prevention of recurrence of life-threatening ventricular tachyarrhythmias; treatment of symptomatic non-sustained ventricular tachyarrhythmias.
Hypersensitivity to sotalol, sulfonamides or other ingredients.
Heart failure IV degree for NYHA, acute and chronic heart failure II-III (under decompensation), acute myocardial infarction, atrioventricular block II-III (if the patient has no functioning pacemaker), ventricular tachycardia of torsade de pointes, sinoatrial block , sick sinus syndrome, symptomatic sinus bradycardia (<50 beats / min), severe dysfunction of the sinus node, congenital or acquired syndrome of long QT interval, severe or uncontrolled congestive heart failure, angina Prinzmetal, cardiogenic shock, renal insufficiency (creatinine clearance <10 ml / min), hypokalemia, hypomagnesaemia, hypotension, expressed by human peripheral blood, asthma and chronic obstructive pulmonary disease, laryngeal edema, allergic rhinitis, metabolic acidosis, untreated pheochromocytoma, diabetes, cardiomegaly (with no signs of heart failure), occlusive disease peripheral vascular disease (complicated by gangrene, “intermittent” claudication or pain at rest), Raynaud’s syndrome, anesthesia drugs that cause depression of the myocardium, concomitant use of MAO-A inhibitors, floktafeninu. Pregnancy or lactation. Children age.
Dosage & Administration
In the treatment of ventricular arrhythmias antiarrhythmics, life-threatening, begin treatment and increase the dose should be in a hospital in the presence of equipment for monitoring and evaluation of heart rate variability.
During treatment, control studies should be conducted at regular intervals (for example, using standard ECG intervals of 1 month or prolonged ECG every 3 months and, if necessary, conduct an electrocardiogram under load).
Therapy should be checked if some parameters deteriorate, for example, increased QRS duration or QT interval is prolonged more than 25% over prolonged PQ interval 50% or increased frequency and severity of arrhythmias.
Severe symptomatic ventricular cardiac arrhythmia
The initial dose – 80 mg sotalol 2 times a day. If the lack of efficacy of therapy, the daily dose can be increased to 80 mg sotalol hydrochloride 3 times daily or 160 mg sotalol hydrochloride 2 times a day.
In case of lack of efficacy in the treatment of arrhythmias, life-threatening patient’s daily dose of sotalol hydrochloride may be increased to 480 mg divided into 2-3 doses.
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