edematous syndrome due to chronic heart failure, cirrhosis of the liver, especially in the presence of hypokalemia and hyperaldosteronism simultaneously;
nephrotic syndrome, edema of pregnancy, and idiopathic cerebral edema;
as an aid in myasthenia gravis, and asthma, paralysis, hypokalemic paroxysmal forms, etc., as well as for the prevention of hypokalemia.
The drug is also used in hypertension to enhance the effect of antihypertensive drugs.
Dosage & Administration
The dose is determined individually taking into account the extent of violations of water-electrolyte balance and hormonal status of the patient.
When edema drug administered in doses of 100-200 mg of (at least – 300 mg) per day, usually in combination with a loop (furosemide, ethacrynic acid) and / or thiazide (hydrochlorothiazide) diuretics. Upon reaching the effective dose of spironolactone reduced to 75-25 mg / day.
Dose correction should be carried out taking into account the concentration of potassium in the blood plasma. In marked hypokalemia and hyperaldosteronism drug administered in a dose of 300 mg / day in 2-3 divided doses. If necessary courses of treatment repeated every 10-14 days.
In hypertensive spironolactone – 25 mg 3-4 times a day.
Hypercalcemia, hyponatremia, anuria, acute renal failure, severe chronic renal failure, I trimester of pregnancy, during lactation.