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Pharmacotherapeutic group: Analgesics. Pyrazolones. Metamizole sodium, combinations with psycholeptics. ATX code N02B B72.
active ingredients: metamizole sodium monohydrate, tempidone (triacetonamine-4-toluenesulfonate);
1 coated tablet contains: metamizole sodium monohydrate 500 mg, tempidone (triacetonamine-4-toluenesulfonate) 20 mg;
excipients: wheat starch, microcrystalline cellulose (type 101), povidone K 25, talc, magnesium stearate; film coating: Opadry II 85 F21526 green (partially hydrolyzed polyvinyl alcohol, macrogol 3350, talc, titanium dioxide (E 171), quinoline yellow (E 104), brilliant blue FCF (E 133)).
Metamizole sodium has analgesic and anti-inflammatory effects. It inhibits the synthesis of prostaglandins, suppressing cyclooxygenase, has a membrane stabilizing effect, and inhibits the formation of endogenous pyrogens.
Tempidone has a pronounced anxiolytic activity and relieves anxiety, fear and tension. Reduces motor excitement, has a central N-anticholinergic effect. Strengthens and lengthens the analgesic effect of metamizole. Tempidone has a beneficial effect on the emotional component of pain. The combination of metamizole sodium and tempidone enhances the analgesic effect of metamizole and increases the duration of its action.
Use during pregnancy or lactation Pregnancy.
Controlled clinical studies in pregnant women have not been conducted, there are no observational data on the use of the drug by this group. Despite the fact that metamizole is a weak inhibitor of prostaglandin synthesis, there is a possibility of premature closure of the Botallovian duct and perinatal complications as a result of a decrease in platelet aggregation in the fetus and mother. Treatment with the drug is contraindicated in pregnant women.
Lactation. Metamizole metabolites pass into breast milk. If treatment with Tempalgin is necessary, breastfeeding should be discontinued.
Store in a dark place and out of reach of children at a temperature not exceeding 25 ºС
Produced in Ukraine
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